Most people think GLP-1 drugs reduce hunger.
That’s the surface.
What they actually do is modify central and peripheral energy governance.
GLP-1 receptors exist in:
• The hypothalamus
• The brainstem
• The pancreas
• The gut
• The cardiovascular system
When activated, they alter:
• POMC neuron activity
• Dopaminergic reward signaling
• Insulin release timing
• Hepatic glucose production
• Gastric motility
Dual agonists (GIP + GLP-1) expand adipocyte signaling.
Triple agonists add glucagon receptor activation, increasing energy expenditure while altering hepatic metabolism.
This isn’t appetite suppression.
It’s metabolic orchestration.
But when you modulate integrated systems, trade-offs emerge.
Lean mass retention.
Energy levels.
Thyroid interaction.
Adaptive thermogenesis.
Self-experimenters need to model system-wide effects.
Not just scale numbers.
We break down full pathway maps inside the Network.
If you aren’t already in the discord reply to this email with DISCORD and I will drop the invite.
PS You can probably find the link somewhere on this email