People love to argue about timing, stacks, “priming,” and whatever the trend-of-the-week is.
But the real separator is simpler:
Duration.
In the transcript, the distinction is crystal clear:
MOTS-C is positioned as foundational (a baseline-style lever)
SS-31 is positioned as cyclical (a targeted tool)
Not because someone wants a fancy story — because the roles are different.
The “forever vs cycle” model
MOTS-C = foundational signal
The idea: you’re replenishing a native signaling molecule that trends lower with age and dysfunction. That’s why it’s described more like “baseline infrastructure” than a short-term gimmick.
SS-31 = repair crew
Potent, targeted, membrane-specific. The logic in the transcript is: if you keep a repair crew on-site when nothing needs repair, the body adapts and the signal becomes “noise.”
So you don’t treat SS-31 like background music.
You treat it like a job:
show up → do the work → leave.
What about “time of day”?
Here’s the only non-negotiable idea worth keeping from the transcript without turning this into dosing advice:
If something’s meant to push metabolic “go” signals, it generally fits better when your system is in “go mode.”
If something’s meant to stabilize structure, consistency matters more than “perfect timing.”
That’s it. No magic. No ritual.
Your action for today (this takes 60 seconds)
Make a two-column list:
Column A: “Baseline upgrades”
Column B: “Targeted repair tools”
Then drop each compound into the bucket it actually belongs in.
This single exercise will save you from 90% of the confusion online — because most people aren’t building protocols, they’re collecting products.
If you are looking for a high quality peptide source I recommend American Peptide Research.
They always have MOTS-C and SS-31 and got RETA and NAD+ back in stock last week.