Most people evaluate compounds by asking:
“What are the side effects?”
That’s incomplete.
There are three layers of risk:
Known side effects
Mechanistic uncertainty
Long-term unknowns
GLP-1 analogs have defined gastrointestinal side effects.
That’s layer one.
But multi-agonists introduce deeper endocrine modulation.
That’s layer two.
Layer three is always present.
Long-term receptor adaptation.
Long-term metabolic shifts.
Long-term tissue-level effects.
That doesn’t mean avoid innovation.
It means understand where the unknowns are.
This is why structured communities matter.
When intelligent adults share documented outcomes, signal emerges faster.
That’s what the Biohacker Network Discord exists for.
No membership fee.
Tomorrow we discuss why centralized medicine moves slowly — and why that isn’t always corruption.